目测本坛有大量中医黑 and 中医粉
西班牙《阿贝赛报》网站9月9日报道称，澳大利亚阿德莱德大学的一个研究团队证实，中国传统中草药具有杀死癌细胞的强大功效。这种中成药已在中国获得批准，用于治疗各种癌症，通常用于辅助西药化疗。让研究人员感到惊讶的是，尽管已验证了这种药物的功效，但对其抗癌原理还一无所知。
发表在《肿瘤学目标》杂志上的上述研究是第一次尝试对中国传统医药的分子作用进行综合性地描述，而不是对每种成分的分子作用进行单独研究。
研究负责人戴维·阿德尔森指出：“大部分中药的使用是基于中国人千百年来的传统经验。有很多证据都证明中药在一些疾病的治疗过程中确实有疗效，但我们并不了解这些药物治疗疾病的具体药理学机制。”
阿德尔森说：“如果我们拆分中国传统医学药方中的成分，会发现单个成分并不会起到好的疗效。各种成分的组合才能显效，而且副作用也小。”
他还指出，这项研究是首次尝试证明从各种中草药中获取的复杂成分的混合物的分子作用方式。澳大利亚研究人员从苦参和白土苓两种中药材的根部提取了成分。
研究人员采用了最先进的测序技术来识别基因和“生物学途径”。这种中医药方作用于乳腺癌肿瘤细胞的培养物。
阿德尔森指出：“我们已证实被中药激活的基因表达方式与西医化疗影响的是相同的生物学途径，只是作用的基因不同。”
他进一步解释说，这些基因能够调节细胞的分裂和生存周期，中药方似乎改变了正在调节中的细胞周期，促使癌细胞朝着死亡的途径上发展，进而最终杀死癌细胞。在这项研究中采用的技术可以用来对其他中草药起效的具体分子生物学机制进行研究，从而为中药在西方社会的使用开辟道路。
http://goo.gl/ys5SVA
Study shows how Chinese medicine kills cancer cells
Thursday, 8 September 2016
Researchers at the University of Adelaide have shown how a complex mix of plant compounds derived from ancient clinical practice in China – a Traditional Chinese Medicine – works to kill cancer cells.
Compound kushen injection (CKI) is approved for use in China to treat various cancer tumours, usually as an adjunct to western chemotherapy – but how it works has not been known.
This study, published in the journal
Oncotarget, is one of the first to characterise the molecular action of a Traditional Chinese Medicine rather than breaking it down to its constituent parts.
“Most Traditional Chinese Medicine are based on hundreds or thousands of years of experience with their use in China,” says study leader,
Professor David Adelson, Director of the
Zhendong Australia – China Centre for the Molecular Basis of Traditional Chinese Medicine.
“There is often plenty of evidence that these medicines have a therapeutic benefit, but there isn’t the understanding of how or why.
“If we broke down and tested the components of many Traditional Chinese Medicines, we would find that individual compounds don’t have much activity on their own. It’s the combination of compounds which can be effective, and potentially means few side-effects as well.
“This is one of the first studies to show the molecular mode of action of a complex mixture of plant-based compounds – in this case extracts from the roots of two medicinal herbs, Kushen and Baituling – by applying what’s known as a systems biology approach. This is a way of analysing complex biological systems that attempts to take into account all measurable aspects of the system rather than focussing on a single variable.”
The Zhendong Australia China Centre for Molecular Traditional Chinese Medicine was established at the University of Adelaide in 2012 in a collaboration with the China-based Shanxi College of Traditional Chinese Medicine and Zhendong Pharmaceutical Company.
The Centre was established with a donation by the Zhendong Pharmaceutical Company, with the aim of understanding how Traditional Chinese Medicine works, and the long-term aim of possible integration into western medicine.
The researchers used high-throughput next generation sequencing technologies to identify genes and biological pathways targeted by CKI when applied to breast cancer cells grown in the laboratory.
“We showed that the patterns of gene expression triggered by CKI affect the same pathways as western chemotherapy but by acting on different genes in the same pathways,” says Professor Adelson.
“These genes regulate the cell cycle of division and death, and it seems that CKI alters the way the cell cycle is regulated to push cancer cells down the cell death pathway, therefore killing the cells.”
Professor Adelson says this technique could be used to analyse the molecular mechanisms of other Traditional Chinese Medicines, potentially opening their way for use in western medicine.
http://goo.gl/Mtmn0D
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