我喝无糖可乐喝了有半年多了，最近开始减肥，在做research的时候发现原来无糖可乐也会发胖的。真是要哭死了....

http://time.com/3746047/diet-soda-bad-belly-fat/

More evidence that diet soda contributes to weight gain, not weight loss

A new study published in the Journal of the American Geriatrics Society found that people who drank diet soda gained almost triple the abdominal fat over nine years as those who didn’t drink diet soda. The study analyzed data from 749 people ages 65 and older who were asked, every couple of years, how many cans of soda they drank a day, and how many of those sodas were diet or regular.

Those answers ended up being extremely predictive of abdominal-fat gain, even after the researchers adjusted for factors like diabetes, smoking and levels of physical activity. People who didn’t drink diet soda gained about 0.8 in. around their waists over the study period, but people who drank diet soda daily gained 3.2 in. Those who fell in the middle — occasional drinkers of diet soda — gained about 1.8 in.

That change in waist circumference is especially concerning because it highlights an unfortunate truth about weight distribution: the belly is a bad place for extra pounds. The kind that pads the abs from the inside, called visceral fat, is associated with increased cardiovascular disease, inflammation and Type 2 diabetes.

These results, which the study authors call “striking,” add to the growing body of evidence that no- and low-calorie sweeteners may come with health concerns. Though scientists are still puzzling through the mechanisms by which diet soda seems to have the unintended consequence of weight gain, they have some ideas. Sugar-free sodas contain substances that sweeten up soda at 200-600 times the sweetness of sugar.

“Regular sugar has caloric consequences,” says the study’s senior author Dr. Helen Hazuda, professor of medicine at the University of Texas Health Science Center at San Antonio. And one of those is that it triggers satiety — a sense of fullness or satisfaction. “Your body is used to knowing that a sweet taste means you are ingesting energy in the form of calories that, if you don’t burn them off, is going to convert to fat,” she says. Artificial sweeteners, however, confuse our bodies and weaken the link in our brains between sweetness and calories. That, Hazuda says, can lead to weight gain and cravings for sweeter and sweeter treats.

There may be something else at work. A recent study in mice showed that artificial sweeteners actually changed the gut bacteria of mice in ways that made them vulnerable to insulin resistance and glucose intolerance — both of which can lead to weight gain. And other mice research suggests that artificial sweeteners are associated with a drop in the appetite-regulating hormone leptin, Hazuda says. Leptin is the hormone that inhibits hunger.

The Calorie Control Council, an association that represents the reduced-calorie food and beverage industry — including alternative sweeteners — disagreed with the study’s findings. “The use of low-calorie sweeteners (LCSs) in weight management has been shown to be beneficial,” the group said in a statement. “While approaches to treat obesity in older individuals is controversial, diet modifications can be a successful part of a weight-management program for older adults.”

Researchers in the new study found that belly-fat gain was most pronounced in people who were already overweight. “People who are already at cardiometabolic risk because they have higher BMIs are really in double or triple jeopardy,” Hazuda says. “When they think they’re doing something good by drinking artificially sweetened beverages, it’s actually totally counterproductive.”

看了以后发现，真的不能投机取巧啊，扰乱大脑对 insulin和 leptin的intake真的作死。我以后再也不喝了！！
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